Wettability and physicochemical characteristics of biphasic calcium
phosphate mixtures depending on the ratio of hydroxyapatite
and <i>β</i> -tricalcium phosphate

Lee, Se Woong; Park, Okmin; Rho, Hyung Tay; Kim, Sang-il; Lee, Se Woong; Park, Okmin; Rho, Hyung Tay; Kim, Sang-il

doi:2023.60.5.811

J. Korean Ceram. Soc. > Volume 60(5); 2023 > Article

Original Article

Journal of the Korean Ceramic Society 2023;60(5): 811-816.
doi: https://doi.org/10.1007/s43207-023-00304-6

Wettability and physicochemical characteristics of biphasic calcium phosphate mixtures depending on the ratio of hydroxyapatite and β -tricalcium phosphate

Se Woong Lee¹, Okmin Park¹, Hyung Tay Rho², Sang-il Kim^1,2

¹Department of Materials Science and Engineering , University of Seoul , Seoul 02504 , South Korea
²Medivalue, Ltd , Seoul 07332 , South Korea

Correspondence

Sang-il Kim ,Email: sang1.kim@uos.ac.kr

Received: February 10, 2023; Revised: April 2, 2023 Accepted: April 5, 2023. Published online: April 18, 2023.

ABSTRACT

Alloplastic grafts are synthetic, inorganic, biocompatible, and bioactive bone substitutes which promote osteoconduction, including hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP). A mixture of HA and β-TCP has been widely used as an alloplastic graft in dental applications, for its ability to modify the biodegradation rate by changing the HA/β-TCP ratio. Wettability is widely known to be a signifi cant and favorable factor for bone grafting materials as it allows immediate exposition to vascular invasion. Herein, a series of xHA-(100–x) β-TCP (x= 0, 10, 30, 50, 70, 90, and 100 wt.%) samples were prepared and their wettability and physicochemical properties were examined. The chemical compositions and structural properties of the samples were studied using X-ray diff raction, Fourier transform infrared spectroscopy, fi eld emission scanning electron microscopy, and energy dispersive X-ray spectroscopy. The pH of the samples in Dulbecco’s modifi ed Eagle’s medium (DMEM) solvent increased from 7.55 to 8.55–9.28, implying the dissolution of the samples and Ca²⁺ release. Contact angle of deionized water on the samples decreased gradually with increasing β-TCP content. HA exhibited low wetting while β-TCP exhibited complete wetting. Therefore, in terms of wettability, good osteogenic ability and workability for a bone grafting material can be achieved by including β-TCP.

Key words: Hydroxyapatite · β-tricalcium phosphate · Wettability · Contact angle