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J. Korean Ceram. Soc. > Volume 57(6); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(6): 597-607.
doi: https://doi.org/10.1007/s43207-020-00090-5
Ceramic layered double hydroxide nanohybrids for therapeutic applications
Wenji Jin1,2, Seongjin Ha1, Jae‑Ha Myung3, Byoung Choul Kim4, Dae‑Hwan Park1
1Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
2College of Chemistry and Environmental Engineering, Jiujiang University, Jiujiang 332005, Jiangxi, People’s Republic of China
3Department of Material Science and Engineering, Incheon National University, Incheon 22012, Republic of Korea
4Division of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
Correspondence  Jae‑Ha Myung ,Email: mjaeha@inu.ac.kr
Byoung Choul Kim ,Email: introbc@gmail.com
Dae‑Hwan Park ,Email: Daehwan.Park@cbnu.ac.kr
Received: November 18, 2019; Revised: November 20, 2019   Accepted: November 22, 2019.  Published online: November 2, 2020.
Layered double hydroxides (LDHs) have attracted considerable interest in bio-related applications owing to their good biocompatibility, biodegradability, facile preparation, and versatile functionality such as tailored drug loading, efcient cellular delivery, targeted delivery, and the controlled release of gene, drug, or other bioactive molecules. In particular, LDHs can accommodate various therapeutic agents and have been extensively explored to achieve novel multifunctional ceramic nanohybrids for therapeutic applications. Here, we review and highlight the recent progresses in ceramic nanohybrids based on LDH materials and their related curative application systems for gene therapy, chemotherapy, phototherapy, and combination therapy. Concretely, the synthetic strategies, structural features, and functions of LDHs as nonviral vectors and their versatile hybrid systems are discussed.
Key words: Layered double hydroxide · Nanohybrid · Gene therapy · Chemotherapy · Phototherapy · Combination therapy
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