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J. Korean Ceram. Soc. > Volume 57(6); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(6): 633-645.
doi: https://doi.org/10.1007%2Fs43207-020-00064-7
Optimized precipitation process for effi cient and size-controlled synthesis of hydroxyapatite–chitosan nanocomposite
Sima Attar Nosrati1, Robabeh Alizadeh1, Seyed Javad Ahmadi2, Mostafa Erfani3
1School of Chemistry, Damghan University, P.O. Box 36715-364, Damghan, Iran
2Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
3Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Correspondence  Robabeh Alizadeh ,Email: alizadeh@du.ac.ir; robabeh_alizadeh@yahoo.com
Received: April 3, 2020; Revised: June 3, 2020   Accepted: June 23, 2020.  Published online: November 30, 2020.
It is known that the physicochemical characteristics of nanocomposites strongly aff ected by synthesis route and conditions. In this study, hydroxyapatite–chitosan nanocomposite as a substance with extensive medical application has been prepared by precipitation method under controlled conditions. To evaluation of the main synthesis parameters, including mixing ratio of precursors, pH and drying condition and investigation of their eff ect on the fi nal products characteristics, a statistical design of experiments approach via Minitab 18 has been applied. For this purpose 12 sets of experimental run have been designed and performed based on various combinations of aforementioned parameters and the characteristics of the prepared samples have been elucidated by means of Fourier transformed infrared spectroscopy, X-ray diff raction, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy and the particle size analysis. The results represent the potential impact of synthesis parameters, their interaction with each other and estimation of optimum synthesis conditions. It is revealed that mean particle size of HA-CS nanocomposite reduced by increasing the content of hydroxyapatite and increment of reaction pH to values higher than 10. Also it is founded that freeze drying process, can be used as a superior drying method for the preparation of HA-CS nanocomposite with uniform particle size.
Key words: Nanocomposite · Hydroxyapatite · Chitosan · Synthesis
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