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J. Korean Ceram. Soc. > Volume 57(3); 2020 > Article
Journal of the Korean Ceramic Society 2020;57(3): 305-313.
doi: https://doi.org/10.1007/s43207-020-00050-z
Synthesis and in vitro bioactivity of three‑dimensionally ordered macroporous‑mesoporous bioactive glasses; 45S5 and S53P4
Reedwan Bin‑Zafar Auniq, Nattawipa Pakasri, Upsorn Boonyang
Functional Materials and Nanotechnology Center of Excellence, School of Science, Walailak University, Nakhon Si Thammarat 80160, Thailand
Correspondence  Upsorn Boonyang ,Email: upsorn.bo@mail.wu.ac.th
Received: December 9, 2019; Revised: January 31, 2020   Accepted: February 15, 2020.  Published online: March 31, 2020.
Two different bioactive glasses, 45S5 ( 45SiO2–24.5CaO–24.5Na2O–6P2O5) and S53P4 ( 53SiO2–20CaO–23Na2O–4P2O5), were synthesized by the sol–gel method using dual-templating methods. Polymethyl methacrylate (PMMA) colloidal crystal used as a template component produced three-dimensionally ordered macroporous (3DOM) structure. Block copolymer, P123, used as a structure-directing agent and template component yielded either mesopores after calcination. The morphology of the 3DOM-mesoporous bioactive glasses (3DOM-MBGs) was observed using a scanning electron microscope. Additionally, energy dispersive spectrometer and inductively coupled plasma-optical emission spectrometry (ICP-OES) were used to confirm the elemental compositions of the samples. Specific surface area and mesopore size distribution were determined using the N2 adsorption–desorption method, where S53P4 glasses exhibited well-ordered mesoporous properties compared to 45S5 glasses. In vitro bioactivity test was performed by soaking the 3DOM-MBGs in a simulated body fluid at 37 °C for 7 days. Results indicated that 45S5 exhibited the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4.
Key words: Glass · Sol–gel process · Ordered macroporous structure · Biomedical applications
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