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J. Korean Ceram. Soc. > Volume 45(10); 2008 > Article
Journal of the Korean Ceramic Society 2008;45(10): 605.
doi: https://doi.org/10.4191/kcers.2008.45.1.605
아미노실란화 철산화물 나노입자를 이용한 Human DNA의 초고속 자성분리
강기호, 장정호
요업기술원 나노소재응용본부 청정.바이오소재팀
High Throughput Magnetic Separation for Human DNA by Aminosilanized Iron Oxide Nanoparticles
Ki-Ho Kang, Jeong-Ho Chang
Eco.Biomaterials Laboratory, Korea Institute of Ceramic Engineering and Technology
ABSTRACT
This work describes the preparation of functionalized magnetic nanoparticles(MNPs) and their bioapplication to human DNA separation. Silica coated MNPs were prepared by changing the volume ratio of tetraethyl orthosilicate(TEOS) for controlled coating thickness on the original nanoparticle of MNPs. The sol-gel process in silica coating on MNPs surface was adapted for relatively mild reaction condition, low-cost, and surfactant-free. And then amino functionalized magnetic nanoparticles were synthesized using amine groups as surface modifiers. The result of adsorption efficiency for human DNA with amino-functionalized silica coated MNPs was calculated as a function of the number of amine groups.
Key words: DNA, Magnetic separation, Nanoparticle, TEOS, Sol-gel
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