Osteoblast Cell Morphology, Proliferation, and Differentiation in Variation with Biomaterials

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doi:2003.40.6.601

J. Korean Ceram. Soc. > Volume 40(6); 2003 > Article

Journal of the Korean Ceramic Society 2003;40(6): 601.
doi: https://doi.org/10.4191/kcers.2003.40.6.601

생체재료의 선택에 따른 조골세포의 형상, 증식 및 분화

김학관, 장주웅, 정희석, 이득용¹

㈜우리동명 치과재료연구소
¹대림대학 재료정보공학과

Osteoblast Cell Morphology, Proliferation, and Differentiation in Variation with Biomaterials

ABSTRACT

Osteoblast-like cell morphology, proliferation, and differentiation were examined in variation with biomaterials. Cells were cultured on TiO$_2$, Ti, 3Y-TZP, HA (Hydroxyapatite) and Thermanox was used as a control specimen. Generally, all specimens have similar cell morphology within the same time interval. However, cells on HA seem to be more thicker than those on TiO$_2$, Ti, 3Y-TZP and cell overlapping was detected very frequently on HA. In case of cell proliferation and differentiation, bioactive material such as HA could help osteoblast-like cell proliferate and provoke a sharp increase of ALP. On the other hand, whether the substrate material is a bioinert ceramics or metal, it does not so strongly affect the cell attachment, proliferation. and differentiation.

Key words: Osteoblast, Morphology, Proliferation, Differentiation, Bioactive, Bioinert