| 다중압출공정을 이용한 알루미나 연속다공질체 제조 및 그의 생체친화성 평가를 위한 In-vitro, In-vivo 실험 |
| 강인철, 조순희1, 송호연1, 이병택 |
공주대학교 나노소재응용공학부
1순천향대학교 의과대학 미생물학교 |
| Fabrication of Continuously Porous Alumina Bodies by Multi-Extrusion Process and their In-vitro and In-vivo Study for Biocompatibility |
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| ABSTRACT |
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To fabricate the continuously porous alumina bodies by multi-extrusion process, carbon powder and ethylene vinyl acetate were used as a pore forming agent and a binder, respectively. As the change of extrusion pass number, reduction ratio as well as the volume fraction of core and tube, the porous alumina bodies having various kind of pore size and porosity could be obtained. The porous bodies showed continuous pore shape, high specific surface as well as high bending strength, which were compared with those of commercial alumina bodies. In-vitro study was carried out using MG-63 osteoblast cells to investigate of their biocompatibility. As a result, the cells grew well on top and bottom as well as inside surface of pore. From the result of in-vivo study of 3-dimensional porous alumina bodies using rats, it was confirmed that any inflammatory response was not found in the subcutaneous tissue around porous body. Also the porous bodies removed from the rats were fully covered with well-developed fibrous tissues and showed the formation of new capillary blood vessels. |
| Key words:
Multi extrusion, Continuously porous body, Alumina, In-vitro, In-vivo |
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