Preparation and Characterization of Water-Soluble Glass through Melting Process (I) : Dissolution Characteristics, Bactericidal Effects and Cytotoxicity

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J. Korean Ceram. Soc. > Volume 32(10); 1995 > Article

Journal of the Korean Ceramic Society 1995;32(10): 1093.

용융법에 의한 수용성 유리의 제조 및 특성 (I) : 용해 특성, 살균 효과 및 세포 독성

조종호, 이용근, 최세영, 신철수¹, 김경남²

연세대학교 세라믹공학과
¹연세대학교 식품·생물공학과
²연세대학교 치과대학

Preparation and Characterization of Water-Soluble Glass through Melting Process (I) : Dissolution Characteristics, Bactericidal Effects and Cytotoxicity

ABSTRACT

Water-soluble phosphate glasses containing Ag or Cu ion were prepared through melting process. Then the powdered glass samples were dissolved in D.I. water at room temperature with changing the dissolution time. In terms with the glass composition, dissolution characteristics, bactericidal effects and cytotoxicities were investigated. Dissolved amounts increased uniformly with dissolution time, and the dissolution rate was higher for ternary glass than for binary glass and with less metal oxide amount. And the dissolution rate of the glass with Ag ion was higher than that with Cu ion, and the bactericidal effect of the glass with Ag ion was also greater. Solution with more than 25 ppm of Ag was observed to have strong cytotoxicity to L929, and solutions of lower Ag concentration or with Cu seemed to have little cytotoxicity.

Key words: Water-soluble, Phosphate glass, Ag ion, Cu ion, Dissolution, Bactericidal effect, Cytotoxicity