Progress and perspectives of metal‑ion‑substituted hydroxyapatite for bone tissue engineering: comparison with hydroxyapatite

Kim, Si Hyun; Park, Cheol Hyun; Heo, Jun Hyuk; Lee, Jung Heon; Kim, Si Hyun; Park, Cheol Hyun; Heo, Jun Hyuk; Lee, Jung Heon

doi:2022.59.3.271

J. Korean Ceram. Soc. > Volume 59(3); 2022 > Article

Review

Journal of the Korean Ceramic Society 2022;59(3): 271-288.
doi: https://doi.org/10.1007/s43207-022-00198-w

Progress and perspectives of metal‑ion‑substituted hydroxyapatite for bone tissue engineering: comparison with hydroxyapatite

Si Hyun Kim³, Cheol Hyun Park¹, Jun Hyuk Heo^1,2, Jung Heon Lee^1,2,3,4

¹School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
²Advanced Materials Technology Research Center, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
³SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
⁴Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea

Correspondence

Jun Hyuk Heo ,Email: saegusa@skku.edu
Jung Heon Lee ,Email: jhlee7@skku.edu

Received: December 21, 2021; Revised: February 8, 2022 Accepted: March 21, 2022. Published online: May 31, 2022.
*Si Hyun Kim and Cheol Hyun Park contributed equally to this work.

ABSTRACT

Hydroxyapatite (HA) is one of the most common bioceramics and is abundant in human bones. HA is composed of calcium phosphate, which is prevalent in biomedical processes, particularly bone formation, osteogenesis, and angiogenesis. As HA is one of the core materials that makes up the human body, there has been considerable research on methods of synthesizing HA while changing its properties by substituting various types of metal ions. In particular, previous studies have intensively investigated the size, crystallinities, and morphologies generated using various synthesis methods to change the characteristics of HA by substituting different metal ions. This review summarizes the findings of these studies on HA, including findings on the characteristics of HA in natural bone, methods of synthesizing HA, and findings on metal-ion-substituted HA. Furthermore, the characteristics and applications of HA that were investigated in previous studies are summarized, and the latest trends and perspectives on the future of the field are also presented.

Key words: Hydroxyapatite (HA) · Metal ions · Substitution · Bone tissue engineering · Osteogenesis